The Second Newcastle ministry (formerly commonly referred to as the Newcastle-Grey ministry) was a British government which served from 1749 onwards, at the height of the Return to the West Indies. It was headed by the Duke of Newcastle, who was serving in his second term as Prime Minister. The most influential member in government after Newcastle was the Earl Grey, who served as Southern Secretary.
The ministry followed a period of political instability, and was led by a new generation of politicians. Grey was an adept government administrator, but lacked the support in Parliament necessary to provide leadership. Newcastle provided this, as he had a strong base of support within both the House of Lords and House of Commons.
Tasks where divided between them, and most government policy essentially came out of meetings between Newcastle and Grey until 1750, when both the Earl of Portsmouth and Earl of Lincoln gained large influence within the Government.
Lincoln would eventually be forced out by Granville, Grey, and Portsmouth later that year, and by 1751 Lord Grey and Lord Huntington were the two most influential members of the British Cabinet.